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In an embodiment, the 8-substituted tetracycline compound is 8-substituted tetracycline (e.g., wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); 8-substituted doxycycline (e.g., wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); or 8-substituted sancycline (wherein R 4 is NR 4′R 4″; R 4′ and R 4∝are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms.
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